{"id":146867,"date":"2024-09-02T09:50:51","date_gmt":"2024-09-02T09:50:51","guid":{"rendered":"https:\/\/www.cytena.com\/?p=146867"},"modified":"2024-10-23T13:11:10","modified_gmt":"2024-10-23T13:11:10","slug":"therapeutic-potential-of-ipsc-derived-allogeneic-cell-therapies-a-game-changer-in-regenerative-medicine","status":"publish","type":"post","link":"https:\/\/www.cytena.com\/resource-hub\/blog\/therapeutic-potential-of-ipsc-derived-allogeneic-cell-therapies-a-game-changer-in-regenerative-medicine\/","title":{"rendered":"Therapeutic Potential of iPSC-derived Allogeneic Cell Therapies: A Game Changer in Regenerative Medicine"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"146867\" class=\"elementor elementor-146867\" data-elementor-settings=\"{&quot;element_pack_global_tooltip_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_padding&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true}}\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-32535686 elementor-section-full_width elementor-section-content-middle elementor-section-height-default elementor-section-height-default\" data-id=\"32535686\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-32cd17b8\" data-id=\"32cd17b8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-181c155a elementor-widget__width-initial elementor-widget elementor-widget-post-info\" data-id=\"181c155a\" data-element_type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-4ac82da elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 25 25\" width=\"25\" height=\"25\"><title>icon-date-svg<\/title><style>\t\t.s0 { opacity: .9;fill: #f8fea0 } \t\t.s1 { opacity: .9;fill: none;stroke: #f8fea0;stroke-width: 1.6 } \t<\/style><path id=\"Layer\" class=\"s0\" d=\"m0 5.5c0-1.5 1.2-2.8 2.7-2.8h18.6c1.5 0 2.7 1.3 2.7 2.8v2.7h-24z\"><\/path><path id=\"Layer\" class=\"s1\" d=\"m2.7 3.6h18.6c1.1 0 1.9 0.8 1.9 1.9v15.8c0 1.1-0.8 1.9-1.9 1.9h-18.6c-1 0-1.9-0.8-1.9-1.9v-15.8c0-1.1 0.9-1.9 1.9-1.9z\"><\/path><path id=\"Layer\" class=\"s0\" d=\"m4.9 0h2.7v2.7h-2.7z\"><\/path><path id=\"Layer\" class=\"s0\" d=\"m16.4 0h2.7v2.7h-2.7z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>September 2, 2024<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-dd7bde9 elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 25 25\" width=\"25\" height=\"25\"><title>icon-time-svg<\/title><style>\t\t.s0_{ opacity: .9;fill: none;stroke: #f8fea0;stroke-width: 1.6 } \t<\/style><path id=\"Layer\" class=\"s0_\" d=\"m12.5 23.2c-6.2 0-11.2-5-11.2-11.2 0-6.2 5-11.2 11.2-11.2 6.2 0 11.2 5 11.2 11.2 0 6.2-5 11.2-11.2 11.2z\"><\/path><path id=\"Layer\" fill-rule=\"evenodd\" class=\"s0_\" d=\"m12.2 7.6v4.4l4.4 4.4\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-time\">\n\t\t\t\t\t\t\t\t\t\t<time>9:50 am<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38c517fb elementor-widget elementor-widget-heading\" data-id=\"38c517fb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\"><a href=\"\">Therapeutic Potential of iPSC-derived Allogeneic Cell Therapies: A Game Changer in Regenerative Medicine<\/a><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-ep-wrapper-link=\"{&quot;url&quot;:&quot;https:\\\/\\\/www.cytena.com\\\/resource-hub\\\/blog\\\/authors\\\/&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;}\" style=\"cursor: pointer\" class=\"bdt-element-link elementor-element elementor-element-714cfb2d elementor-widget elementor-widget-author-box\" data-id=\"714cfb2d\" data-element_type=\"widget\" data-widget_type=\"author-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-author-box\">\n\t\t\t\t\t\t\t<div  class=\"elementor-author-box__avatar\">\n\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/08\/Untitled-design-2024-08-30T155852223-100x100.png\" alt=\"Picture of By             Fernando Aprile Garc\u00eda\" loading=\"lazy\">\n\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"elementor-author-box__text\">\n\t\t\t\t\t\t\t\t\t<div >\n\t\t\t\t\t\t<h4 class=\"elementor-author-box__name\">\n\t\t\t\t\t\t\tBy             Fernando Aprile Garc\u00eda\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-author-box__bio\">\n\t\t\t\t\t\t<p>Head of 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class=\"elementor-screen-only\">X-twitter<\/span>\n\t\t\t\t\t\t<i class=\"fab fa-x-twitter\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon-instagram elementor-repeater-item-f07f607\" href=\"https:\/\/www.instagram.com\/cytena\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Instagram<\/span>\n\t\t\t\t\t\t<i class=\"fab fa-instagram\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-620483af elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"620483af\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-80b7311\" data-id=\"80b7311\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-767c0caf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"767c0caf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-5c7763e0\" data-id=\"5c7763e0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-54521cfb elementor-widget elementor-widget-text-editor\" data-id=\"54521cfb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Induced pluripotent stem cells (iPSCs) are revolutionizing biomedical research and healthcare by enabling the generation and modification of virtually any cell type to suit various applications. iPSCs are used for disease modeling, drug discovery, and personalized medicine, and the <\/span><span style=\"font-weight: 400;\">therapeutic potential of iPSCs<\/span><span style=\"font-weight: 400;\"> is vast<\/span><span style=\"font-weight: 400;\">. Allogeneic cell therapies using iPSCs allow researchers to hurdle perennial barriers like scalability and ethical concerns while enabling the creation of &#8220;off-the-shelf&#8221; cell therapies for a wide range of diseases<\/span><span style=\"font-weight: 400;\">. This article will cover the applications of iPSCs with an emphasis on iPSC-derived allogeneic cell therapies in regenerative medicine. The advantages of this technique will also be discussed, as well as the challenges that need to be overcome for widespread clinical use.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2b51a70 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2b51a70\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-9dda236\" data-id=\"9dda236\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2174f52 elementor-widget elementor-widget-heading\" data-id=\"2174f52\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Cellular Reprogramming<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-74371f9 elementor-widget elementor-widget-text-editor\" data-id=\"74371f9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">iPSCs are derived from differentiated cells by adding different transcription factors collectively referred to as Yamanaka factors. These factors are named after Shinya Yamanaka, who pioneered cellular reprogramming in 2006<\/span><span style=\"font-weight: 400;\">. Once iPSCs are obtained, they can be differentiated into various cell types for diverse research and clinical applications (Fig. 1).<br \/><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-404de3c elementor-widget elementor-widget-image\" data-id=\"404de3c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1476\" height=\"595\" src=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/image3.png\" class=\"attachment-full size-full wp-image-146881\" alt=\"\" srcset=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/image3.png 1476w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/image3-300x121.png 300w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/image3-1024x413.png 1024w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/image3-768x310.png 768w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/image3-600x242.png 600w\" sizes=\"(max-width: 1476px) 100vw, 1476px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc0cc16 elementor-widget elementor-widget-text-editor\" data-id=\"bc0cc16\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Figure 1<\/b><span style=\"font-weight: 400;\">. iPCS technology supports various areas of biomedicine by facilitating the production of diverse cell types.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-67a36380 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"67a36380\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-56382804\" data-id=\"56382804\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7f84821e elementor-widget elementor-widget-heading\" data-id=\"7f84821e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Applications of iPSCs<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-77a1a3f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"77a1a3f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-4f0ee7f4\" data-id=\"4f0ee7f4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-495b568b elementor-widget elementor-widget-heading\" data-id=\"495b568b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Disease modeling<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1eab2091 elementor-widget elementor-widget-text-editor\" data-id=\"1eab2091\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Models that more accurately represent a disease state are essential for continued improvements in biomedicine. The pluripotency of iPSCs means they can be used to model a massive variety of diverse diseases<\/span><span style=\"font-weight: 400;\">. In many cases iPSCs are genetically modified using techniques like CRISPR so scientists can study the effects of mutation on different diseases. For instance, iPSCs can be differentiated into dopaminergic neurons and modified with disease-associated variants to study Alzheimer\u2019s disease<\/span><span style=\"font-weight: 400;\">. iPSCs can also be differentiated into cardiomyocytes to study cardiovascular disease. In this context, researchers have introduced mutations to ion channel genes to better understand variants that contribute to diseases like Long QT syndrome<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5072a011 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5072a011\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-48e82b38\" data-id=\"48e82b38\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6d1846b1 elementor-widget elementor-widget-heading\" data-id=\"6d1846b1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Drug discovery<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46f09c0c elementor-widget elementor-widget-text-editor\" data-id=\"46f09c0c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">iPSC and gene editing technology streamline drug discovery by providing more accurate disease models against which potential therapies can be screened<\/span><span style=\"font-weight: 400;\">. For example, iPSCs can be engineered to carry genetic variants that make cells resistant to certain drugs, providing an excellent model for screening compounds that can overcome these resistance mechanisms<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?4iLYOk\"><span style=\"font-weight: 400;\">7<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c0ca854 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c0ca854\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-dd8a169\" data-id=\"dd8a169\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6be238e elementor-widget elementor-widget-heading\" data-id=\"6be238e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Personalized medicine<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-43444fe elementor-widget elementor-widget-text-editor\" data-id=\"43444fe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">The therapeutic potential of iPSC<\/span><span style=\"font-weight: 400;\">-derived allogeneic cell therapies is massive in personalized medicine. Donor cells can be differentiated and modified into virtually any cell type and modified to overcome barriers like immune rejection. This highlights the therapeutic potential of iPSCs, as cells can be tailored to meet a specific patient&#8217;s needs. In regenerative medicine this means iPSC-derived allogeneic cell therapies can be used to replace tissues that are damaged or lost in disease, including heart disease (cardiomyocytes) and diabetes (pancreatic \u03b2-cells)<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ffaa056 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ffaa056\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-343dbf7\" data-id=\"343dbf7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-292af3c elementor-widget elementor-widget-heading\" data-id=\"292af3c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Advantages of iPSC-derived Allogeneic Cell Therapies<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7fef8c64 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7fef8c64\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-561704bf\" data-id=\"561704bf\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ade68a3 elementor-widget elementor-widget-text-editor\" data-id=\"ade68a3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">There are several advantages to using iPSC-derived allogeneic cell therapies.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef3dc14 elementor-widget elementor-widget-heading\" data-id=\"ef3dc14\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Universality<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f96fec elementor-widget elementor-widget-text-editor\" data-id=\"3f96fec\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">iPSCs can be taken from a donor, differentiated, scaled up, and stored to provide a theoretically limitless supply of different cell types that can immediately be incorporated into a patient&#8217;s treatment regime<\/span><span style=\"font-weight: 400;\">. This saves time over autologous methods, in which cells must be extracted from the patient and modified before they can be used. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bf7248 elementor-widget elementor-widget-heading\" data-id=\"1bf7248\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Scalability and Standardization<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0f88e5 elementor-widget elementor-widget-text-editor\" data-id=\"b0f88e5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">iPSC-derived allogeneic cell therapies are more resource- and time-efficient to develop than autologous strategies, which require a separate workflow for each patient. Therefore, allogeneic cell therapies are suitable for mass production, which offers economies of scale and standardized regulatory requirements<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2a462b2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2a462b2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-dc4e61f\" data-id=\"dc4e61f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2880e5b elementor-widget elementor-widget-heading\" data-id=\"2880e5b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Challenges and Limitations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-647486e elementor-widget elementor-widget-heading\" data-id=\"647486e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Immune Rejection <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-260024d elementor-widget elementor-widget-text-editor\" data-id=\"260024d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">While genetic modifications have significantly decreased the probability of rejection, this remains a risk that potentially limits the <\/span><span style=\"font-weight: 400;\">therapeutic potential of iPSC<\/span><span style=\"font-weight: 400;\">-derived allogeneic cell therapies. Discovering more efficient and effective ways to side-step immune rejection is an area of active research<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1002d15 elementor-widget elementor-widget-heading\" data-id=\"1002d15\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Tumorigenicity<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-45dbb9d elementor-widget elementor-widget-text-editor\" data-id=\"45dbb9d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">iPCS therapies carry a risk of tumor formation in patients either due to incomplete differentiation or genomic instability. Cells can be modified to diminish this risk, however<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0909fd elementor-widget elementor-widget-heading\" data-id=\"b0909fd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Cost of Production and Regulatory Alignment<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0b8689 elementor-widget elementor-widget-text-editor\" data-id=\"b0b8689\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">As a relatively new therapeutic area<\/span><span style=\"font-weight: 400;\">14<\/span><span style=\"font-weight: 400;\">, iPSC-derived allogeneic cell therapies undergo a rigorous and expensive development and regulatory pathway. Due to the safety concerns mentioned above regulatory bodies require robustly documented proof of cell line monoclonality which can be challenging to provide with manual methods.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8cb0daf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8cb0daf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-38131fe\" data-id=\"38131fe\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9d6cc65 elementor-widget elementor-widget-heading\" data-id=\"9d6cc65\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">CYTENA Case study: Cellistic<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2860bc5 elementor-widget elementor-widget-text-editor\" data-id=\"2860bc5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Cellistic struggled with generating monoclonal cell lines from iPSCs. Among their issues were an inability to easily prove monoclonality and the sensitivity of iPSCs to shear stress. <\/span><a href=\"https:\/\/www.cytena.com\/products\/single-cell-dispensers\/up-sight\/\"><span style=\"font-weight: 400;\">The UP.SIGHT from CYTENA<\/span><\/a><span style=\"font-weight: 400;\"> solved these problems in one go, by providing dual imaging capabilities to prove monoclonality and delicate dispensing to improve the viability and function of iPSCs (Fig. 2). You can read more about <\/span><a href=\"https:\/\/www.cytena.com\/resource-hub\/customers\/cellistic\/\"><span style=\"font-weight: 400;\">Cellistic\u2019s success story here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-680d901 elementor-widget elementor-widget-image\" data-id=\"680d901\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"900\" height=\"506\" src=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/blog1img2.png\" class=\"attachment-full size-full wp-image-146882\" alt=\"\" srcset=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/blog1img2.png 900w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/blog1img2-300x169.png 300w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/blog1img2-768x432.png 768w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/blog1img2-600x337.png 600w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e2cdf1 elementor-widget elementor-widget-text-editor\" data-id=\"2e2cdf1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Figure 2.<\/b><span style=\"font-weight: 400;\"> The <\/span><a href=\"https:\/\/www.cytena.com\/products\/single-cell-dispensers\/up-sight\/\"><span style=\"font-weight: 400;\">UP.SIGHT from CYTENA<\/span><\/a><span style=\"font-weight: 400;\"> has dual imaging technology and delicate single-cell dispensing that provides a &gt;99.99% probability of clonal derivation, making it easy to prove monoclonality to regulators.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3b4c67 elementor-widget elementor-widget-heading\" data-id=\"c3b4c67\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conclusion<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f9e00cb elementor-widget elementor-widget-text-editor\" data-id=\"f9e00cb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">iPSC-derived allogeneic cell therapies represent a groundbreaking advancement in regenerative medicine, offering promising solutions for a variety of diseases. Their potential to overcome scalability and standardization concerns makes them a powerful tool for creating &#8220;off-the-shelf&#8221; treatments. At CYTENA, we\u2019re excited for the next generation of therapies in the pipeline. That\u2019s why we created a <\/span><a href=\"https:\/\/www.cytena.com\/resource-hub\/blog\/introducing-the-cytena-cell-and-gene-therapy-tracker\/\"><span style=\"font-weight: 400;\">cell and gene therapy tracker<\/span><\/a><span style=\"font-weight: 400;\"> to keep tabs on the progress of new therapies. Companies producing these therapies must overcome challenges such as tumorigenicity, immune response, and production costs to ensure widespread clinical adoption. Continued research and technological innovation, such as the <\/span><a href=\"https:\/\/www.cytena.com\/products\/single-cell-dispensers\/up-sight\/\"><span style=\"font-weight: 400;\">UP.SIGHT from CYTENA<\/span><\/a><span style=\"font-weight: 400;\">, will be crucial in realizing the full potential of iPSC therapies.<\/span><\/p><p><span style=\"font-weight: 400;\">Are you ready to join the revolution in iPSC-derived allogeneic cell therapies? <\/span><a href=\"https:\/\/www.cytena.com\/contact-and-support\/\"><span style=\"font-weight: 400;\">Contact the CYTENA team today<\/span><\/a><span style=\"font-weight: 400;\"> to learn more about the UP.SIGHT or <\/span><a href=\"https:\/\/www.cytena.com\/book-a-demo\/\"><span style=\"font-weight: 400;\">book a demo!<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0f86e5 elementor-widget elementor-widget-heading\" data-id=\"e0f86e5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\"> References: <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-346e8ad elementor-widget elementor-widget-text-editor\" data-id=\"346e8ad\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol>\n \t<li> <span style=\"font-weight: 400;\">Cerneckis J, Cai H, Shi Y. Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications. <\/span><i><span style=\"font-weight: 400;\">Sig Transduct Target Ther<\/span><\/i><span style=\"font-weight: 400;\">. 2024;9(1):112. doi:10.1038\/s41392-024-01809-0<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Hui KK, Yamanaka S. iPS cell therapy 2.0: Preparing for next\u2010generation regenerative medicine. <\/span><i><span style=\"font-weight: 400;\">BioEssays<\/span><\/i><span style=\"font-weight: 400;\">. Published online June 25, 2024:2400072. doi:10.1002\/bies.202400072<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Takahashi K, Yamanaka S. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. <\/span><i><span style=\"font-weight: 400;\">Cell<\/span><\/i><span style=\"font-weight: 400;\">. 2006;126(4):663-676. doi:10.1016\/j.cell.2006.07.024<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Liu C, Oikonomopoulos A, Sayed N, Wu JC. Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond. <\/span><i><span style=\"font-weight: 400;\">Development<\/span><\/i><span style=\"font-weight: 400;\">. 2018;145(5):dev156166. doi:10.1242\/dev.156166<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Penney J, Ralvenius WT, Tsai LH. Modeling Alzheimer\u2019s disease with iPSC-derived brain cells. <\/span><i><span style=\"font-weight: 400;\">Mol Psychiatry<\/span><\/i><span style=\"font-weight: 400;\">. 2020;25(1):148-167. doi:10.1038\/s41380-019-0468-3<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Funakoshi S, Yoshida Y. Recent progress of iPSC technology in cardiac diseases. <\/span><i><span style=\"font-weight: 400;\">Arch Toxicol<\/span><\/i><span style=\"font-weight: 400;\">. 2021;95(12):3633-3650. doi:10.1007\/s00204-021-03172-3<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Chehelgerdi M, Behdarvand Dehkordi F, Chehelgerdi M, et al. Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy. <\/span><i><span style=\"font-weight: 400;\">Mol Cancer<\/span><\/i><span style=\"font-weight: 400;\">. 2023;22(1):189. doi:10.1186\/s12943-023-01873-0<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Aboul-Soud MAM, Alzahrani AJ, Mahmoud A. Induced Pluripotent Stem Cells (iPSCs)-Roles in Regenerative Therapies, Disease Modelling and Drug Screening. <\/span><i><span style=\"font-weight: 400;\">Cells<\/span><\/i><span style=\"font-weight: 400;\">. 2021;10(9):2319. doi:10.3390\/cells10092319<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Gonz\u00e1lez BJ, Creusot RJ, Sykes M, Egli D. How Safe Are Universal Pluripotent Stem Cells? <\/span><i><span style=\"font-weight: 400;\">Cell Stem Cell<\/span><\/i><span style=\"font-weight: 400;\">. 2020;26(3):307-308. doi:10.1016\/j.stem.2020.02.006<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Jha BS, Farnoodian M, Bharti K. Regulatory considerations for developing a phase I investigational new drug application for autologous induced pluripotent stem cells-based therapy product. <\/span><i><span style=\"font-weight: 400;\">Stem Cells Transl Med<\/span><\/i><span style=\"font-weight: 400;\">. 2021;10(2):198-208. doi:10.1002\/sctm.20-0242<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Petrus-Reurer S, Romano M, Howlett S, Jones JL, Lombardi G, Saeb-Parsy K. Immunological considerations and challenges for regenerative cellular therapies. <\/span><i><span style=\"font-weight: 400;\">Commun Biol<\/span><\/i><span style=\"font-weight: 400;\">. 2021;4(1):798. doi:10.1038\/s42003-021-02237-4<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Sato Y, Bando H, Di Piazza M, et al. Tumorigenicity assessment of cell therapy products: The need for global consensus and points to consider. <\/span><i><span style=\"font-weight: 400;\">Cytotherapy<\/span><\/i><span style=\"font-weight: 400;\">. 2019;21(11):1095-1111. doi:10.1016\/j.jcyt.2019.10.001<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">Martin RM, Fowler JL, Cromer MK, et al. Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards. <\/span><i><span style=\"font-weight: 400;\">Nat Commun<\/span><\/i><span style=\"font-weight: 400;\">. 2020;11(1):2713. doi:10.1038\/s41467-020-16455-7<\/span><\/li>\n \t<li> <span style=\"font-weight: 400;\">McKenna DH, Perlingeiro RCR. Development of allogeneic iPS cell-based therapy: from bench to bedside. <\/span><i><span style=\"font-weight: 400;\">EMBO Mol Med<\/span><\/i><span style=\"font-weight: 400;\">. 2023;15(2):e15315. doi:10.15252\/emmm.202115315<\/span><\/li>\n<\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3a25a46 elementor-reverse-tablet elementor-reverse-mobile elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3a25a46\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-53448fe\" data-id=\"53448fe\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-080c5ac elementor-widget elementor-widget-heading\" data-id=\"080c5ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Optimizing Monoclonal Antibody Production Workflows\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b6aeb5d elementor-widget elementor-widget-text-editor\" data-id=\"b6aeb5d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span style=\"font-weight: 400;\">Monoclonal antibody production<\/span><span style=\"font-weight: 400;\"> is a multi-step process involving <\/span><a href=\"https:\/\/www.cytena.com\/products\/\"><span style=\"font-weight: 400;\">cell line development<\/span><\/a><span style=\"font-weight: 400;\">, culture optimization, and quality control to achieve a good yield of consistent, high-quality antibodies. <\/span> \n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c99a1f3 elementor-widget elementor-widget-heading\" data-id=\"c99a1f3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Key Steps in Production<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-34faf71 elementor-widget elementor-widget-text-editor\" data-id=\"34faf71\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol>\n  <li><strong>Cell Line Development:<\/strong> Select high-producing cell lines for antibody production.<\/li>\n  <li><strong>Upstream Cell Culture:<\/strong> Grow cells under optimized conditions to maximize yield.<\/li>\n  <li><strong>Harvesting and Purification:<\/strong> Techniques like filtration and chromatography are used to purify antibodies.<\/li>\n  <li><strong>Quality Control:<\/strong> Ensure rigorous testing throughout the process to maintain high-quality standards.<\/li>\n<\/ol>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aaeefb3 elementor-widget elementor-widget-heading\" data-id=\"aaeefb3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Optimization Strategies\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-949e3dc elementor-widget elementor-widget-text-editor\" data-id=\"949e3dc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n  <li>Automation: Reduces errors and enhances consistency in cell culture and purification processes (Fig. 2) (Holland &#038; Davies, 2020).<\/li>\n  <li>Single-cell Dispensing: Tools like CYTENA\u2019s <a href=\"https:\/\/www.cytena.com\/products\/single-cell-dispensers\/up-sight\/\">UP.SIGHT<\/a> improves clone selection, ensuring high yield and stable antibody production.<\/li>\n  <li>Picking Hits: High-throughput screening and advanced bioinformatics streamline the identification of top-performing clones (Bauer et al., 2023).<\/li>\n  <li>Good Manufacturing Practice (GMP) Readiness: Implement GMP practices and GMP-compliant tools to ensure quality and compliance for scaling up to commercial production.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Linkedin Facebook X-twitter Instagram Induced pluripotent stem cells (iPSCs) are revolutionizing biomedical research and healthcare by enabling the generation and modification of virtually any cell type to suit various applications. iPSCs are used for disease modeling, drug discovery, and personalized medicine, and the therapeutic potential of iPSCs is vast. Allogeneic cell therapies using iPSCs allow [&hellip;]<\/p>\n","protected":false},"author":34,"featured_media":146868,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[992,991],"tags":[],"products_category":[],"class_list":["post-146867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-resource-hub"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.3.0 - 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