{"id":146878,"date":"2024-09-23T10:10:45","date_gmt":"2024-09-23T10:10:45","guid":{"rendered":"https:\/\/www.cytena.com\/?p=146878"},"modified":"2024-10-28T12:39:26","modified_gmt":"2024-10-28T12:39:26","slug":"unlocking-the-future-of-medicine-the-promise-and-techniques-of-allogeneic-stem-cell-therapies","status":"publish","type":"post","link":"https:\/\/www.cytena.com\/resource-hub\/blog\/unlocking-the-future-of-medicine-the-promise-and-techniques-of-allogeneic-stem-cell-therapies\/","title":{"rendered":"Unlocking the Future of Medicine: The Promise and Techniques of Allogeneic Stem Cell Therapies"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"146878\" class=\"elementor elementor-146878\" 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data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-32535686 elementor-section-full_width elementor-section-content-middle elementor-section-height-default elementor-section-height-default\" data-id=\"32535686\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-32cd17b8\" data-id=\"32cd17b8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-181c155a elementor-widget__width-initial elementor-widget elementor-widget-post-info\" data-id=\"181c155a\" data-element_type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div 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0h2.7v2.7h-2.7z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>September 23, 2024<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-dd7bde9 elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 25 25\" width=\"25\" height=\"25\"><title>icon-time-svg<\/title><style>\t\t.s0_{ opacity: .9;fill: none;stroke: #f8fea0;stroke-width: 1.6 } \t<\/style><path id=\"Layer\" class=\"s0_\" d=\"m12.5 23.2c-6.2 0-11.2-5-11.2-11.2 0-6.2 5-11.2 11.2-11.2 6.2 0 11.2 5 11.2 11.2 0 6.2-5 11.2-11.2 11.2z\"><\/path><path id=\"Layer\" fill-rule=\"evenodd\" class=\"s0_\" d=\"m12.2 7.6v4.4l4.4 4.4\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-time\">\n\t\t\t\t\t\t\t\t\t\t<time>10:10 am<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38c517fb elementor-widget elementor-widget-heading\" data-id=\"38c517fb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Unlocking the Future of Medicine: The Promise and Techniques of Allogeneic Stem Cell Therapies<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-ep-wrapper-link=\"{&quot;url&quot;:&quot;https:\\\/\\\/www.cytena.com\\\/resource-hub\\\/blog\\\/authors\\\/&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;}\" style=\"cursor: pointer\" class=\"bdt-element-link elementor-element 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class=\"elementor-screen-only\">X-twitter<\/span>\n\t\t\t\t\t\t<i class=\"fab fa-x-twitter\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon-instagram elementor-repeater-item-f07f607\" href=\"https:\/\/www.instagram.com\/cytena\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Instagram<\/span>\n\t\t\t\t\t\t<i class=\"fab fa-instagram\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-620483af elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"620483af\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-80b7311\" data-id=\"80b7311\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-767c0caf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"767c0caf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-5c7763e0\" data-id=\"5c7763e0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-54521cfb elementor-widget elementor-widget-text-editor\" data-id=\"54521cfb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span style=\"font-weight: 400;\">Stem cell technologies are responsible for some of the most exciting areas of modern healthcare. A core element of this is the use of allogeneic <\/span><span style=\"font-weight: 400;\">stem cell therapy<\/span><span style=\"font-weight: 400;\"> in regenerative medicine. These therapies use donor-derived somatic cells, which are dedifferentiated into induced pluripotent stem cells (iPSC). From here, iPSCs can be differentiated into virtually any cell type to replace damaged or dead tissue in patients<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?BqQC1d\"><span style=\"font-weight: 400;\"><sup>1<\/sup><\/span><\/a><span style=\"font-weight: 400;\">. The production process is complex, but new technologies in areas like automation are helping researchers overcome long-standing challenges<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?ajVu3Z\"><span style=\"font-weight: 400;\"><sup>2<\/sup><\/span><\/a><span style=\"font-weight: 400;\">. This article covers the exciting potential of allogeneic <\/span><span style=\"font-weight: 400;\">stem cell therapy<\/span><span style=\"font-weight: 400;\">, how they are generated, and how automation is streamlining their production and advancing the next generation of iPSC-based therapies (Fig. 1).<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-770b795 elementor-widget elementor-widget-image\" data-id=\"770b795\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1280\" height=\"720\" src=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img1.png\" class=\"attachment-full size-full wp-image-146888\" alt=\"\" srcset=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img1.png 1280w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img1-300x169.png 300w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img1-1024x576.png 1024w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img1-768x432.png 768w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img1-600x338.png 600w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c512d40 elementor-widget elementor-widget-text-editor\" data-id=\"c512d40\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Figure 1.<\/b> <span style=\"font-weight: 400;\">Stem cell therapy<\/span><span style=\"font-weight: 400;\"> is used to treat conditions like neurodegenerative and cardiovascular disease.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-67a36380 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"67a36380\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-56382804\" data-id=\"56382804\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7f84821e elementor-widget elementor-widget-heading\" data-id=\"7f84821e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Therapeutic Potential of Allogeneic Stem Cell Therapy<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b3f27eb elementor-widget elementor-widget-text-editor\" data-id=\"1b3f27eb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Stem cell therapies have the potential to treat a wide range of diseases, especially in the field of regenerative medicine<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?Ckaumf\"><span style=\"font-weight: 400;\"><sup>1<\/sup><\/span><\/a><span style=\"font-weight: 400;\">. They also have critical applications in research and development.<\/span><b><\/b><\/p><ul><li aria-level=\"1\"><b>Disease Modeling &#8211; <\/b><span style=\"font-weight: 400;\">The versatility of <\/span><span style=\"font-weight: 400;\">iPSC techniques<\/span><span style=\"font-weight: 400;\"> makes them fantastic for generating models of a massive range of diseases<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?QLXbQr\"><span style=\"font-weight: 400;\"><sup>3<\/sup><\/span><\/a><span style=\"font-weight: 400;\">. Furthermore, they can be genetically modified to express disease-associated genetic variants<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?cRVVh7\"><span style=\"font-weight: 400;\"><sup>4<\/sup><\/span><\/a><span style=\"font-weight: 400;\">. <\/span><\/li><li aria-level=\"1\"><b style=\"font-style: inherit;\">Drug Discovery &#8211; <\/b><span style=\"font-weight: 400;\">iPSCs are used to generate cells that more closely resemble disease conditions, enabling more accurate testing of potential drugs<\/span><a style=\"font-size: 16px; background-color: #ffffff;\" href=\"https:\/\/www.zotero.org\/google-docs\/?tqXsLy\"><span style=\"font-weight: 400;\"><sup>5<\/sup><\/span><\/a><span style=\"font-weight: 400;\">. For instance, iPSCs can be differentiated into neurons and modified to express genetic variants associated with Alzheimer\u2019s disease<\/span><a style=\"font-size: 16px; background-color: #ffffff;\" href=\"https:\/\/www.zotero.org\/google-docs\/?xQLiFu\"><span style=\"font-weight: 400;\"><sup>6<\/sup><\/span><\/a><span style=\"font-weight: 400;\">. Researchers can use these cells in high-throughput assays to test how potential drugs affect the disease mechanisms and neuronal function.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7fef8c64 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7fef8c64\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-561704bf\" data-id=\"561704bf\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0378753 elementor-widget elementor-widget-heading\" data-id=\"0378753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Medicine<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ade68a3 elementor-widget elementor-widget-text-editor\" data-id=\"ade68a3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span style=\"font-weight: 400;\">iPSC-derived allogeneic cell therapies hold great promise in personalized medicine. They allow donor cells to be transformed into various cell types and engineered to avoid immune rejection. This adaptability makes them valuable for regenerative medicine, offering potential treatments for diseases like heart disease (cardiomyocytes) and diabetes (pancreatic \u03b2-cells)<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?xjyjao\"><span style=\"font-weight: 400;\"><sup>1,4<\/sup><\/span><\/a><span style=\"font-weight: 400;\">.<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef3dc14 elementor-widget elementor-widget-heading\" data-id=\"ef3dc14\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Advantages<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f96fec elementor-widget elementor-widget-text-editor\" data-id=\"3f96fec\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Universality<\/b><span style=\"font-weight: 400;\"> &#8211; Allogeneic <\/span><span style=\"font-weight: 400;\">stem cell therapy<\/span><span style=\"font-weight: 400;\"> can theoretically be given to any individual, making them an <\/span><span style=\"font-weight: 400;\">\u201coff-the-shelf\u201d<\/span><span style=\"font-weight: 400;\"> solution for several diseases for which there is an urgent medical need<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?Iy2a9u\"><span style=\"font-weight: 400;\"><sup>7<\/sup><\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><b style=\"font-style: inherit;\">Scalability<\/b><span style=\"font-weight: 400;\"> &#8211; Their universality makes these cells suitable for large-scale production, leading to cost savings and improved standardization<\/span><a style=\"font-size: 16px; background-color: #ffffff;\" href=\"https:\/\/www.zotero.org\/google-docs\/?M4I09T\"><span style=\"font-weight: 400;\"><sup>8<\/sup><\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bf7248 elementor-widget elementor-widget-heading\" data-id=\"1bf7248\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Challenges<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0f88e5 elementor-widget elementor-widget-text-editor\" data-id=\"b0f88e5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li aria-level=\"1\"><b>Immune Rejection &#8211; <\/b><span style=\"font-weight: 400;\">While these cells are often modified to overcome immune rejection, it remains challenging to apply them as therapies in some instances<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?I8DamI\"><span style=\"font-weight: 400;\"><sup>9<\/sup><\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n \t<li aria-level=\"1\"><b>Tumorigenicity &#8211; <\/b><span style=\"font-weight: 400;\">iPSC-based therapies can carry a risk of tumor development in patients, though this can also be reduced via genetic modifications<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?IyuC8l\"><span style=\"font-weight: 400;\"><sup>10<\/sup><\/span><\/a><span style=\"font-weight: 400;\">. <\/span><b style=\"font-style: inherit;\"><\/b><\/li>\n \t<li aria-level=\"1\"><b style=\"font-style: inherit;\">Cost &#8211; <\/b><span style=\"font-weight: 400;\">These therapies are relatively expensive to produce, though allogeneic therapies benefit from economies of scale that autologous therapies do not<\/span><a style=\"font-size: 16px; background-color: #ffffff;\" href=\"https:\/\/www.zotero.org\/google-docs\/?4hsHSS\"><span style=\"font-weight: 400;\"><sup>11<\/sup><\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-36fafd3 elementor-widget elementor-widget-text-editor\" data-id=\"36fafd3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">We have only scratched the surface of how allogeneic stem cells can transform regenerative medicine. For a more detailed discussion read our full article on this topic.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2a462b2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2a462b2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-dc4e61f\" data-id=\"dc4e61f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2880e5b elementor-widget elementor-widget-heading\" data-id=\"2880e5b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Core Methods<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fa79901 elementor-widget elementor-widget-text-editor\" data-id=\"fa79901\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Generating iPSC-based allogeneic cell therapies is a long and complicated process, and researchers must overcome many challenges and potential pitfalls to produce a high quality <\/span><span style=\"font-weight: 400;\">stem cell therapy<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-647486e elementor-widget elementor-widget-heading\" data-id=\"647486e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Process<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dd406c1 elementor-widget elementor-widget-text-editor\" data-id=\"dd406c1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li aria-level=\"1\"><b>Reprogramming and Modification &#8211; <\/b><span style=\"font-weight: 400;\">Somatic cells are dedifferentiated to a pluripotent state by the addition of transcription factors known collectively as Yamanaka factors<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?zMSCac\"><span style=\"font-weight: 400;\"><sup>12<\/sup><\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n \t<li aria-level=\"1\"><b>Selection &#8211; <\/b><span style=\"font-weight: 400;\">Single iPSCs are seeded into individual wells to facilitate the growth of monoclonal populations. <\/span><a href=\"https:\/\/www.cytena.com\/products\/single-cell-dispensers\/up-sight\/\"><span style=\"font-weight: 400;\">The UP.SIGHT from CYTENA<\/span><\/a><span style=\"font-weight: 400;\"> provides gentle dispensing and &gt;97% single-cell dispensing efficiency. This <\/span><a href=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2023\/04\/UP.SIGHT-iPSC-Application-Note.pdf\"><span style=\"font-weight: 400;\">application note<\/span><\/a><span style=\"font-weight: 400;\"> demonstrates how the UP.SIGHT addresses common challenges in iPSC dispensing and cultivation.<\/span><\/li>\n \t<li aria-level=\"1\"><b>Quality Control (QC) &#8211; <\/b><span style=\"font-weight: 400;\">Robust QC processes control for potential issues like loss of pluripotency, contamination, and genomic instability. QC is performed throughout the development process<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?ZQFjys\"><span style=\"font-weight: 400;\"><sup>13<\/sup><\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n \t<li aria-level=\"1\"><b>Scaling &#8211; <\/b><span style=\"font-weight: 400;\">Scaling up occurs both at the iPSC stage and after iPSCs have been differentiated so there is a stock of differentiated cells ready for clinical use.<\/span><\/li>\n \t<li aria-level=\"1\"><b style=\"font-style: inherit;\">Storing &#8211; <\/b><span style=\"font-weight: 400;\">iPSCs are typically cryopreserved at 196\u00b0C with intermediate cooling steps<\/span><a style=\"font-size: 16px; background-color: #ffffff;\" href=\"https:\/\/www.zotero.org\/google-docs\/?6Mk0ty\"><span style=\"font-weight: 400;\"><sup>14<\/sup><\/span><\/a><span style=\"font-weight: 400;\">. Improper storage can affect downstream function.<\/span><\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6f1df2 elementor-widget elementor-widget-heading\" data-id=\"f6f1df2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Therapy Success Story - Aloficel<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62ec568 elementor-widget elementor-widget-text-editor\" data-id=\"62ec568\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tCrohn\u2019s is a chronic inflammatory disease that can lead to the development of perianal fistulas, which are abnormal tunnel-like connections between the rectum or anus and the surrounding skin. Perianal fistulas cause symptoms, including pain, discharge, and recurring infections<a href=\"https:\/\/www.zotero.org\/google-docs\/?RHfaRX\"><sup>15<\/sup><\/a>. Aloficel is an allogeneic stem cell therapy that uses mesenchymal stem cells derived from the adipose tissue of adult donors. It is now approved for use in the EU and\u00a0 Japan and is administered during surgery to help reduce inflammation and repair damaged tissue<a href=\"https:\/\/www.zotero.org\/google-docs\/?stZNFd\"><sup>16,17<\/sup><\/a>. Aloficel demonstrates the power of allogeneic stem cell therapies in tackling challenging conditions that have historically been difficult to manage.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ea8ea3 elementor-widget elementor-widget-heading\" data-id=\"4ea8ea3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Future Technologies<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f956ffd elementor-widget elementor-widget-text-editor\" data-id=\"f956ffd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>3D printing technologies allow iPSCs to be integrated into biomaterials and organoids, providing better disease models and functional cell-based therapeutics for tissue regeneration. Organoids are particularly promising for use in the early stages of drug development to better recapitulate complex diseases (Fig. 2)<strong><a href=\"https:\/\/www.zotero.org\/google-docs\/?13b1kO\"><sup>18<\/sup><\/a><\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fa58999 elementor-widget elementor-widget-image\" data-id=\"fa58999\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1280\" height=\"948\" src=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img2.png\" class=\"attachment-full size-full wp-image-146889\" alt=\"\" srcset=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img2.png 1280w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img2-300x222.png 300w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img2-1024x758.png 1024w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img2-768x569.png 768w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img2-600x444.png 600w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6af1701 elementor-widget elementor-widget-text-editor\" data-id=\"6af1701\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Figure 2<\/b><span style=\"font-weight: 400;\">. Organoids offer a more realistic model for disease than monoclonal cell lines.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09bc003 elementor-widget elementor-widget-text-editor\" data-id=\"09bc003\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">For more information on how iPSC-based therapies are produced and the associated challenges, read our full article, which covers these topics in more detail.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3a25a46 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3a25a46\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-53448fe\" data-id=\"53448fe\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-080c5ac elementor-widget elementor-widget-heading\" data-id=\"080c5ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Benefits of Automation in iPSC Therapy Production<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b6aeb5d elementor-widget elementor-widget-text-editor\" data-id=\"b6aeb5d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Automation confers numerous benefits that streamline production and enhance the quality of the final product.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c99a1f3 elementor-widget elementor-widget-heading\" data-id=\"c99a1f3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Efficiency and Scale<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27a16ce elementor-widget elementor-widget-text-editor\" data-id=\"27a16ce\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span style=\"font-weight: 400;\">When performed manually, single-cell seeding is prone to errors, contamination, and time loss, which slows development. Automated processes, such as those that incorporate the <\/span><a href=\"https:\/\/www.cytena.com\/products\/single-cell-dispensers\/up-sight\/\"><span style=\"font-weight: 400;\">UP.SIGHT from CYTENA<\/span><\/a><span style=\"font-weight: 400;\">, provide faster cell seeding and a &gt;99.99% probability of clonal derivation. Automation also supports resource efficiency by allowing workflows to be scaled down<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?yiFaTl\"><span style=\"font-weight: 400;\"><sup>19<\/sup><\/span><\/a><span style=\"font-weight: 400;\">.<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-afae823 elementor-widget elementor-widget-heading\" data-id=\"afae823\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Higher Throughput<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe9a765 elementor-widget elementor-widget-text-editor\" data-id=\"fe9a765\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Liquid handlers that use automation can dispense cells and media more accurately and quickly than manual methods. This means more cells can be seeded in the same workflow. When coupled with dedicated software like <\/span><a href=\"https:\/\/www.cytena.com\/products\/single-cell-dispensers\/c-studio\/\"><span style=\"font-weight: 400;\">CYTENA\u2019s C.STUDIO<\/span><\/a><span style=\"font-weight: 400;\">, automation makes it simple to screen thousands of clones and identify the best ones to proceed with.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6fb5cca elementor-widget elementor-widget-heading\" data-id=\"6fb5cca\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Regulatory Compliance<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16a6c68 elementor-widget elementor-widget-text-editor\" data-id=\"16a6c68\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span style=\"font-weight: 400;\">Regulatory bodies require proof of monoclonality before approving cell-based therapies<\/span><a href=\"https:\/\/www.zotero.org\/google-docs\/?rmomO5\"><span style=\"font-weight: 400;\"><sup>11<\/sup><\/span><\/a><span style=\"font-weight: 400;\">. The <\/span><a href=\"https:\/\/www.cytena.com\/products\/single-cell-dispensers\/up-sight\/\"><span style=\"font-weight: 400;\">UP.SIGHT from CYTENA<\/span><\/a><span style=\"font-weight: 400;\"> possesses dual imaging capabilities that image single cells as they are dispensed and after they settle in the well, helping researchers side-step common regulatory pitfalls in cell therapy development (Fig. 3).<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6407df7 elementor-widget elementor-widget-image\" data-id=\"6407df7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"358\" height=\"385\" src=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img3.png\" class=\"attachment-full size-full wp-image-146890\" alt=\"\" srcset=\"https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img3.png 358w, https:\/\/www.cytena.com\/wp-content\/uploads\/2024\/09\/b4img3-279x300.png 279w\" sizes=\"(max-width: 358px) 100vw, 358px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8fbe190 elementor-widget elementor-widget-text-editor\" data-id=\"8fbe190\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Figure 3. <\/b><a href=\"https:\/\/www.cytena.com\/products\/single-cell-dispensers\/up-sight\/\"><span style=\"font-weight: 400;\">The UP.SIGHT<\/span><\/a><span style=\"font-weight: 400;\"> makes it easy to prove monoclonality to regulators and gives researchers confidence in their cell line development workflows.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fc2c52e elementor-widget elementor-widget-text-editor\" data-id=\"fc2c52e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">For more information on this topic, including how automation reduces the risk of contamination and improves workflow reliability, read our full-length article.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2ec2b64 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ec2b64\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-54d9f6d\" data-id=\"54d9f6d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b4cba39 elementor-widget elementor-widget-heading\" data-id=\"b4cba39\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conclusion<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14a0ede elementor-widget elementor-widget-text-editor\" data-id=\"14a0ede\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Allogeneic <\/span><span style=\"font-weight: 400;\">stem cell therapy<\/span><span style=\"font-weight: 400;\"> holds immense promise in transforming regenerative medicine and drug discovery. By leveraging iPSCs, these therapies offer versatile solutions for treating various diseases. We created a <\/span><a href=\"https:\/\/www.cytena.com\/resource-hub\/blog\/introducing-the-cytena-cell-and-gene-therapy-tracker\/\"><span style=\"font-weight: 400;\">tracker to monitor the cell and gene therapy pipeline<\/span><\/a><span style=\"font-weight: 400;\">, highlighting clinical trial progress and regulatory approvals. Automation helps researchers overcome common hurdles in therapy development by streamlining production processes, improving efficiency, and facilitating regulatory compliance. As technology advances, the future of allogeneic stem cell therapies is becoming even brighter, opening up new opportunities for personalized medicine and large-scale treatments.<\/span><\/p><p><span style=\"font-weight: 400;\">CYTENA\u2019s suite of high-end instrumentation supports ambitious researchers striving to produce the next generation of regenerative medicines. Contact our team to learn more about the <\/span><a href=\"https:\/\/www.cytena.com\/products\/single-cell-dispensers\/up-sight\/\"><span style=\"font-weight: 400;\">UP.SIGHT single cell dispenser<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><a href=\"https:\/\/www.cytena.com\/book-a-demo\/\"><span style=\"font-weight: 400;\">Book a demo<\/span><\/a><span style=\"font-weight: 400;\"> to explore its capabilities first hand.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8890859 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8890859\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-99995b9\" data-id=\"99995b9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-12d6c20 elementor-widget elementor-widget-heading\" data-id=\"12d6c20\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">References<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5c1607a elementor-widget elementor-widget-text-editor\" data-id=\"5c1607a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li><span style=\"font-weight: 400;\">Aboul-Soud MAM, Alzahrani AJ, Mahmoud A. Induced Pluripotent Stem Cells (iPSCs)-Roles in Regenerative Therapies, Disease Modelling and Drug Screening. <\/span><i><span style=\"font-weight: 400;\">Cells<\/span><\/i><span style=\"font-weight: 400;\">. 2021;10(9):2319. doi:10.3390\/cells10092319<\/span><\/li><li><span style=\"font-weight: 400;\">Doulgkeroglou MN, Di Nubila A, Niessing B, et al. Automation, Monitoring, and Standardization of Cell Product Manufacturing. <\/span><i><span style=\"font-weight: 400;\">Front Bioeng Biotechnol<\/span><\/i><span style=\"font-weight: 400;\">. 2020;8:811. doi:10.3389\/fbioe.2020.00811<\/span><\/li><li><span style=\"font-weight: 400;\">Liu C, Oikonomopoulos A, Sayed N, Wu JC. Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond. <\/span><i><span style=\"font-weight: 400;\">Development<\/span><\/i><span style=\"font-weight: 400;\">. 2018;145(5):dev156166. doi:10.1242\/dev.156166<\/span><\/li><li><span style=\"font-weight: 400;\">Nicholson MW, Ting CY, Chan DZH, et al. Utility of iPSC-Derived Cells for Disease Modeling, Drug Development, and Cell Therapy. <\/span><i><span style=\"font-weight: 400;\">Cells<\/span><\/i><span style=\"font-weight: 400;\">. 2022;11(11):1853. doi:10.3390\/cells11111853<\/span><\/li><li><span style=\"font-weight: 400;\">Elitt MS, Barbar L, Tesar PJ. Drug screening for human genetic diseases using iPSC models. <\/span><i><span style=\"font-weight: 400;\">Human Molecular Genetics<\/span><\/i><span style=\"font-weight: 400;\">. 2018;27(R2):R89-R98. doi:10.1093\/hmg\/ddy186<\/span><\/li><li><span style=\"font-weight: 400;\">Penney J, Ralvenius WT, Tsai LH. Modeling Alzheimer\u2019s disease with iPSC-derived brain cells. <\/span><i><span style=\"font-weight: 400;\">Mol Psychiatry<\/span><\/i><span style=\"font-weight: 400;\">. 2020;25(1):148-167. doi:10.1038\/s41380-019-0468-3<\/span><\/li><li><span style=\"font-weight: 400;\">Gonz\u00e1lez BJ, Creusot RJ, Sykes M, Egli D. How Safe Are Universal Pluripotent Stem Cells? <\/span><i><span style=\"font-weight: 400;\">Cell Stem Cell<\/span><\/i><span style=\"font-weight: 400;\">. 2020;26(3):307-308. doi:10.1016\/j.stem.2020.02.006<\/span><\/li><li><span style=\"font-weight: 400;\">Jha BS, Farnoodian M, Bharti K. Regulatory considerations for developing a phase I investigational new drug application for autologous induced pluripotent stem cells-based therapy product. <\/span><i><span style=\"font-weight: 400;\">Stem Cells Transl Med<\/span><\/i><span style=\"font-weight: 400;\">. 2021;10(2):198-208. doi:10.1002\/sctm.20-0242<\/span><\/li><li><span style=\"font-weight: 400;\">Petrus-Reurer S, Romano M, Howlett S, Jones JL, Lombardi G, Saeb-Parsy K. Immunological considerations and challenges for regenerative cellular therapies. <\/span><i><span style=\"font-weight: 400;\">Commun Biol<\/span><\/i><span style=\"font-weight: 400;\">. 2021;4(1):798. doi:10.1038\/s42003-021-02237-4<\/span><\/li><li><span style=\"font-weight: 400;\">Sato Y, Bando H, Di Piazza M, et al. Tumorigenicity assessment of cell therapy products: The need for global consensus and points to consider. <\/span><i><span style=\"font-weight: 400;\">Cytotherapy<\/span><\/i><span style=\"font-weight: 400;\">. 2019;21(11):1095-1111. doi:10.1016\/j.jcyt.2019.10.001<\/span><\/li><li><span style=\"font-weight: 400;\">McKenna DH, Perlingeiro RCR. Development of allogeneic iPS cell-based therapy: from bench to bedside. <\/span><i><span style=\"font-weight: 400;\">EMBO Mol Med<\/span><\/i><span style=\"font-weight: 400;\">. 2023;15(2):e15315. doi:10.15252\/emmm.202115315<\/span><\/li><li><span style=\"font-weight: 400;\">Cerneckis J, Cai H, Shi Y. Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications. <\/span><i><span style=\"font-weight: 400;\">Sig Transduct Target Ther<\/span><\/i><span style=\"font-weight: 400;\">. 2024;9(1):112. doi:10.1038\/s41392-024-01809-0<\/span><\/li><li><span style=\"font-weight: 400;\">Madrid M, Lakshmipathy U, Zhang X, et al. Considerations for the development of iPSC-derived cell therapies: a review of key challenges by the JSRM-ISCT iPSC Committee. <\/span><i><span style=\"font-weight: 400;\">Cytotherapy<\/span><\/i><span style=\"font-weight: 400;\">. Published online June 2024:S1465324924007308. doi:10.1016\/j.jcyt.2024.05.022<\/span><\/li><li><span style=\"font-weight: 400;\">Yuan Y, Yang Y, Tian Y, et al. Efficient long-term cryopreservation of pluripotent stem cells at \u221280 \u00b0C. <\/span><i><span style=\"font-weight: 400;\">Sci Rep<\/span><\/i><span style=\"font-weight: 400;\">. 2016;6(1):34476. doi:10.1038\/srep34476<\/span><\/li><li><span style=\"font-weight: 400;\">Lee JL, Yoon YS, Yu CS. Treatment Strategy for Perianal Fistulas in Crohn Disease Patients: The Surgeon\u2019s Point of View. <\/span><i><span style=\"font-weight: 400;\">Ann Coloproctol<\/span><\/i><span style=\"font-weight: 400;\">. 2021;37(1):5-15. doi:10.3393\/ac.2021.02.08<\/span><\/li><li><span style=\"font-weight: 400;\">Mezey \u00c9. Human Mesenchymal Stem\/Stromal Cells in Immune Regulation and Therapy. <\/span><i><span style=\"font-weight: 400;\">Stem Cells Translational Medicine<\/span><\/i><span style=\"font-weight: 400;\">. 2022;11(2):114-134. doi:10.1093\/stcltm\/szab020<\/span><\/li><li><span style=\"font-weight: 400;\">Takeda Receives Approval to Manufacture and Market Alofisel\u00ae\u25bc (darvadstrocel) in Japan for Treatment of Complex Perianal Fistulas in Patients with Non-active or Mildly Active Luminal Crohn\u2019s Disease. Accessed September 30, 2024. https:\/\/www.takeda.com\/newsroom\/newsreleases\/2021\/takeda-receives-approval-to-manufacture-and-market-alofisel-darvadstrocel-in-japan-for-treatment-of-complex-perianal-fistulas-in-patients-with-non-active-or-mildly-active-luminal-crohns-disease\/<\/span><\/li><li><span style=\"font-weight: 400;\">Soman SS, Vijayavenkataraman S. Applications of 3D Bioprinted-Induced Pluripotent Stem Cells in Healthcare. <\/span><i><span style=\"font-weight: 400;\">Int J Bioprint<\/span><\/i><span style=\"font-weight: 400;\">. 2020;6(4):280. doi:10.18063\/ijb.v6i4.280<\/span><\/li><li><span style=\"font-weight: 400;\">Holland I, Davies JA. Automation in the Life Science Research Laboratory. <\/span><i><span style=\"font-weight: 400;\">Front Bioeng Biotechnol<\/span><\/i><span style=\"font-weight: 400;\">. 2020;8(571777). doi:10.3389\/fbioe.2020.571777<\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Linkedin Facebook X-twitter Instagram Stem cell technologies are responsible for some of the most exciting areas of modern healthcare. A core element of this is the use of allogeneic stem cell therapy in regenerative medicine. These therapies use donor-derived somatic cells, which are dedifferentiated into induced pluripotent stem cells (iPSC). From here, iPSCs can be [&hellip;]<\/p>\n","protected":false},"author":34,"featured_media":146879,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[992,991],"tags":[],"products_category":[],"class_list":["post-146878","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-resource-hub"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.3.0 - 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